Á¶Çõ(Cho Hyuck) - Kyung Hee University College of Medicine Department of Pathology
ÀÓ¼ºÁ÷(Lim Sung-Jig) - Kyung Hee University Hospital at Gangdong Department of Pathology
¿ø±Ô¿¬(Won Kyu-Yeoun) - Kyung Hee University Hospital at Gangdong Department of Pathology
¹è°íÀº(Bae Go-Eun) - Kyung Hee University Graduate School of Medicine Departments of Pathology
±è±³¿µ(Kim Gou-Young) - Kyung Hee University Hospital at Gangdong Department of Pathology
¹ÎÁö¿ø(Min Ji-Won) - Kyung Hee University Graduate School of Medicine Departments of Pathology
³ëº´ÁÖ(Noh Byeong-Joo) - Kyung Hee University School of Medicine Department of Pathology
Abstract
Background: A decrease in the number of tissue eosinophils is known to reflect the malignancy potential of neoplastic lesions and even prognosis. Increased levels of the chemokines CCL11 and CCL24 in serum and tissue are also known to have diagnostic value as serum tumor markers or prognostic factors. The aim of this study was to evaluate the correlation between the degree of tissue eosinophilia and the expression of these chemokines in the glandular and stromal cells of colorectal neoplastic lesions ranging from benign to malignant tumors.
Methods: We counted the number of infiltrating eosinophils in neoplastic lesion tissue and we evaluated the expression of CCL11 and CCL24 in glandular cells and stromal cells by immunohistochemical staining.
Results: The results showed that the number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase.
Conclusions: The discrepancy in CCL11 and CCL24 expression between glandular cells and stromal cells might shed light on how colorectal cancer evades the immune system, which would enable further development of immunotherapies that target these chemokines. Further research on eosinophil biology and the expression pattern of chemokines in tumor cells is needed.
Å°¿öµå
Eosinophils, CCL11, CCL24, Colorectal neoplasms
KMID :
1039420160500010045
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À¯È¿¼º°á°ú(Recomendation)
The number of eosinophils decreased significantly and the expression of CCL11 and CCL24 in glandular cells decreased with tumor progression, whereas the stromal expression of CCL11 and CCL24 appeared to increase.